Investigation of a Blood transfusion Reaction
Donor- Recipient compatibility for ABO taking account of clinically significant allo-antibodies in the recipient. The mechanism of haemolysis depends on the class of the antibody and its availability of fix complement. Haemolytic transfusion Reaction(HTR) 1. Acute Intravascular Extra Vaskular 2. Delayed - Mainly extravascular Acute : Intravascular Haemolysis : It is potentially fatal and is usually due to ABO in compatibility. Serological Investigation: Specimens required. 1. Per transfusion serum and red cells of the patient. 2. Post trans serum and red cells of the patient. 3. Urine from the patient for the first 24 hrs of the reaction. This will be dark and presence of hemoglobin in the case of intra vascular haemolysis. Serological Test: 1. Confirm the ABO and RH groups of the patient's pre and post transfusion samples and the donor ...
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